Construction and analysis of regulatory networks in breast cancer (Record no. 4909)

MARC details
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control field 20220107122808.0
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Transcribing agency
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Personal name Mahima V S (93514007)
9 (RLIN) 8202
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Title Construction and analysis of regulatory networks in breast cancer
502 ## - DISSERTATION NOTE
Degree type Master of Philosophy in Computer Science
Name of granting institution 2014-2015
Year degree granted EXT
-- Elizabeth Sherly
-- Umesh P <br/>(Dept. of Computational Biology and Bioinformatics )<br/>
Miscellaneous information "Dept. of Computational Biology and Bioinformatics <br/>University of Kerala"
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Summary, etc. Breast cancer is a complex and heterogeneous disease having different pathological<br/>conditions. Identification of genes associated with breast cancer provides helpful information which can be used for providing better treatment and personalized medicines.Numerous methodologies are now available to examine the genes regulated by breast cancer. Recent advances in Bioinformatics have enabled to analyze the data obtained from various sources such as microarray, ChIP-Seq, RNA-Seq etc. Analyses of the differential expression obtained from RNA-Seq data provide useful information for the construction and analysis of biological networks. For this work, six RNA-Seq control cell lines data obtained from NCBI (a public repository) have been analyzed to obtain the differential expression using the standard RNA-seq pipeline. GFold is used to get the rank of differentially expressed genes. Common up-regulated and down-regulated genes in all the cell lines and uniquely regulated genes in each cell line has been annotated using DAVID and WebGestalt for biological interpretations. Inferring of KEGG pathway and gene ontologies of regulated genes (up and down) gives some interesting results. Regulation of action cytoskeleton, MAPK signaling, wnt signaling, VEGF signaling pathway, cell adhesion molecules are the pathways significantly over represented in up-regulated genes. Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction are the pathways significantly associated with down-regulated genes.<br/>
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Topical term or geographic name entry element THEORY OF COMPUTATION
9 (RLIN) 8203
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Topical term or geographic name entry element DYNAMIC PROGRAMMING
9 (RLIN) 8204
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Topical term or geographic name entry element REGULATORY NETWORKS
9 (RLIN) 8205
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Source of classification or shelving scheme Dewey Decimal Classification
Koha item type
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Date acquired Total Checkouts Barcode Date last seen Price effective from Koha item type
    Dewey Decimal Classification     IIITM-K Kerala University of Digital Sciences, Innovation and Technology Knowledge Centre 26/02/2016   R-626 26/02/2016 26/02/2016 Project Reports