Computational study of the effect of polysaccharide encapsulation on anti-cancer property of imatinib (Record no. 4944)

MARC details
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fixed length control field 01937nam a22001817a 4500
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control field OSt
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control field 20220107122808.0
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Transcribing agency
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Personal name Priya.R (92213011)
9 (RLIN) 8339
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Title Computational study of the effect of polysaccharide encapsulation on anti-cancer property of imatinib
502 ## - DISSERTATION NOTE
Degree type Master of Science in Computational Science
Name of granting institution 2013-2015
Year degree granted EXT
-- T.K Manoj Kumar
-- T.T Sreelekha ( Assistant Professor )
Miscellaneous information "Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (RCC)"
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Summary, etc. Imatinib is an antineoplastic agent used against Chronic Myeloid Leukemia (CML), Gastrointestinal Stromal Tumors (GISTs) and various other malignancies. Its action is different than other drugs in that it specifically targets an enzyme that allows CML cells to grow. Drug resistance associated with imatinib is the main problem facing in the treatment of patients. Nanoscale drug encapsulation becomes an outstanding approach to the medical field, thereby, avoids the side effects that occur in the traditional cancer treatment. Structure based drug design offers a computational approach to find out a lead compound that could become a drug. The present computational study aimed at the modification of a drug which is used for treating cancer patients for better results. A model of Galactoxyloglucan encapsulated Imatinib has been developed and computed the activity of this encapsulated drug against various cancer causing pathways such as DNA topoisomerase 2-beta(3QX3), Epidermal growth factor receptor(1M17) and Tyrosine-protein kinase ABL1(3QRJ). Computations indicate that the polysaccharide encapsulated drug is highly effective and targeted towards different cancer causing pathways.
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Topical term or geographic name entry element APPLIED COMPUTING
9 (RLIN) 8340
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Topical term or geographic name entry element PHYSICAL SCIENCES AND ENGINEERING
9 (RLIN) 8341
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Topical term or geographic name entry element CHEMISTRY
9 (RLIN) 8342
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    Dewey Decimal Classification     IIITM-K Kerala University of Digital Sciences, Innovation and Technology Knowledge Centre 02/03/2016   R-658 02/03/2016 02/03/2016 Project Reports